1.
Bioorg Med Chem Lett
; 12(12): 1687-90, 2002 Jun 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12039591
RESUMO
A series of para-substituted 3-phenyl pyrazolopyrimidines was synthesized and evaluated as inhibitors of lck. The nature of the substitution affected enzyme selectivity and potency for lck, src, kdr, and tie-2. The para-phenoxyphenyl analogue 2 is an orally active lck inhibitor with a bioavailability of 69% and exhibits an extended duration of action in animal models of T cell inhibition.